Bioactivity of Some Egyptian Seaweeds Extract

Eman H. Hamza1, Tarek A. Temraz2, and Safwat A. Ahmed3

Abstract

ABSTRACT

This research aimed at screening in vivo antioxidant and anti-inflammatory activities as well as in vitro

antimicrobial and cytotoxic activities in Codium tomentosum, Ulva lactuca and Hypnea musciformis,

collected form the Suez Canal, Egypt. Samples were cleaned from epiphytes, washed, air dried and

powdered. All the methanol/methylene chloride crude extracts showed a marked antioxidant effect

compared to the reference drug vitamin E on alloxan induced diabetic rats and Hypnea musciformis (red

algae) was the most potent (60.18%). Also, it showed the maximum anti-inflammatory activity in

carrageenan-induced rat paw edema. Both extracts of H. musciformis and U. lactuca showed a wide

spectrum antibacterial activity, and the highest activity appeared against Klebsiella pneumoniae (clinical

culture). Moreover, all the crude extracts showed a promising cytotoxic activity (> 70%) against liver

(HEPG2) and prostrate (PC3) cancer cell lines using Sulpho-Rhodamine-B (SRB) assay. The ethyl acetate

fractions of U. lactuca, C. tomentosum and H. musciformis were significantly enhanced in HEPG2 with

IC50 (12.8, 24.5 and 17.8 μg/ml), respectively, compared to the control doxorubicin. Such biological

activities might be attributed to the presence of phenols, flavonoids, and tannins, as active constituents in

all algal extracts. Besides Alkaloids observed in U. lactuca and H. musciformis, as well as saponins from

U. lactuca.


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